Ascorbate peroxidases (or APX1) are enzymes that detoxify peroxides such as hydrogen peroxide using ascorbate as a substrate. The reaction they catalyse is the transfer of electrons from ascorbate to a peroxide, producing dehydroascorbate and water as products.[1]
Ascorbate + Hydrogen peroxide → Dehydroascorbate + Water
C6H8O6 + H2O2 → C6H6O6 + 2 H2O
APX is an integral component of the glutathione-ascorbate cycle.[2] These enzymes are commonly hemoproteins and the haem cofactor is the site of the oxidation-reduction reaction shown above.[3]
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